Cardiac Researchers at National Heart Centre Singapore Acquire First SyncroPatch 384/768PE in Asia

The SyncroPatch 384/768 Patch Engine: HTS-compatible patch clamp-based ion channel drug discovery. (PresseBox) (München, ) Scientific Director Dr. Winston Shim and his research group aim at restoring compromised heart tissue by using stem cell therapies. To promote their research they recently invested in several Nanion platforms for patch clamped-based ion channel screening, characterization, and cardiotoxicity screening.
The SyncroPatch 384/768PE is an advanced robotic screening platform that is used to investigate the effects of chemical compounds and toxins on ion channel function. The instrument supports high quality recordings from up to 768 cells simultaneously, allowing high throughput screening of ligand- and voltage-gated ion channels expressed in cell lines, stem cells or patient-derived cells.
The SyncroPatch 384PE/768 PE combines high versatility and data quality by offering fast solution exchange, brief compound exposure, internal perfusion and minimal cell usage. The minimal cell usage application improves cost efficiency while allowing screening capabilities with cells of limited availability such as primary cells or otherwise rare and expensive stem cells or patient-derived cells.
Nanion's Patchliner, a high quality, automated patch clamp platform recording from eight cells in parallel, and the CardioExcyte 96, a 96-well plate based platform for contractility and electrical activity measurements from cellular networks, are acknowledged for their utility in cardiac safety and toxicity screening.

Dr. Winston Shim, Principal Scientist, National Heart Centre Singapore, says:
"I find the performance and technical capabilities of the SyncroPatch 384/768PE convincing. In particular, the fact that stem cell-derived cardiomyocytes can be measured with reasonable success rates, and the optimized cell handling procedure, which reduces input cell numbers, is appealing when working with patient-derived cardiomyocytes and other clinical samples. Additionally, Nanion's Patchliner that supports automated current clamp recordings at physiological temperatures is highly attractive when investigating action potentials and drug-induced alterations. In combination with the CardioExcyte 96, it opens the possibility to investigate acute and chronic effects of chemical compounds on beating cardiac syncytium from our work on cardiac maturation. Going forward, I believe that such enabling platforms will galvanize our work in human cardiomyocytes from disease modeling to drug discovery and regenerative medicine."

The CiPA initiative, commenced by HESI and the FDA, aims at expanding the mandatory cardiac ion channels from two to five in safety screening efforts, thus demanding higher throughput capabilities and the ability to use stem cell-derived cardiomyocytes in cardiotoxicity screening. Here, Nanion’s APC platforms the SyncroPatch 384/768PE and the Patchliner, constitute an excellent complement to the CardioExcyte 96 covering the range from in vitro cellular network studies to in-depth ion channel safety studies.


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